chromosome	gene symbol	phenotype
21q22.1	SOD1 superoxide dismutase 1, soluble	Amyotrophic lateral sclerosis, due to SOD1 deficiency -ALS Amyotrophic lateral sclerosis 1 -ALS1
21q22.1-q22.2	KCNE1 potassium voltage-gated channel, Isk-related family, member 1	Long QT syndrome-5 -LQT5 Jervell and Lange-Nielsen syndrome -JLNS1
21q22.12	KCNE2 potassium voltage-gated channel, Isk-related family, member 2	Long QT syndrome-6 -LQT6 Atrial fibrillation, 1 -ATFB1
21q22.3	COL6A1 alpha 1 type VI collagen	Bethlem myopathy - Ullrich congenital muscular dystrophy -UCMD Ossification of the posterior longitudinal spinal ligaments -OPLL
21q22.3	COL6A2 alpha 2 type VI collagen	Bethlem myopathy - Ullrich scleroatonic muscular dystrophy -UCMD